Clinico-pathological and immunohistochemical findings in a case of bovine cutaneous angiomatosis in a Holstein heifer

ABSTRACT: Bovine cutaneous angiomatosis (BCA) is a rare condition characterized by vasoproliferative skin lesions mainly affecting cattle in the northern hemisphere. An eight-month-old Holstein heifer showed two easy-bleeding nodules bulging from epidermis forehead and close to right prescapular region. Skin were within dermis had an irregular surface soft heterogeneous reddish parenchyma composed of numerous variable-sized arterioles, veins, capillaries surrounded abundant collagenous fibrous tissue. Immunohistochemical assays evidenced endothelial cells lining proliferative vascular structure immunolabeled for CD31 Von Willebrand factor, smooth muscle immunostained actin. All clinical, pathological, immunohistochemical features observed hallmarks BCA. Considering its potential hereditary spread, BCA must be included differential diagnosis easily bleeding that do not respond routine topical wound treatments prevent spread Brazilian herds.